Webinar: The importance of the extracellular matrix for stem cell differentiation on July 9 (Tuesday), 8:00am PST

Webinar- The importance of the extracellular matrix for stem cell differentiation

July 9, 2013 8:00am PST presented by Marie Zhang Ph.D. of MicroStem, Inc.

Please register at: https://attendee.gotowebinar.com/register/7145863858983675904

Increasing evidence has demonstrated that a local microenvironment - a stem niche, is important in regulating their self-renewal and differentiation in tissue and organ development process. Such microenvironment consists of many factors including extracellular matrices (ECMs), growth factors, signalling molecules, etc. Although soluble factors such as FGFs, BMPs and Wnts have been well studied for their role in regulating stem cell behaviour, the effect of cell-matrix interaction in stem cell development is poorly understood. The ECM as a major microenvironment component provides not only a scaffold for cellular support, but also as storage reservoir for growth factors, hormones and cytokines. Although in the in vivo microenvironment, multiple ECMs can be present simultaneously working in concert with other soluble factors to regulate stem cell fate, current existing technology can only allow researcher to exam ECM effect one at a time. MicroStem’s MicroMatrixTM technology is a ‘spot-array’-platform that creates hundreds to thousands of microscopic environments. Specifically, a microscope glass slide is functionalized with a proprietary hydrogel on the surface. This hydrogel provides a certain degree of surface stiffness for stem cells to reside on. Proteins such as extracellular matrix proteins (ECMPs), signaling molecules, growth factors, cell adhesion molecules, glycans, antibodies, etc. are deposited onto the hydrogel surface as printed array spots. Such high content array system allows the studies of multiple cell phenotypic behaviors simultaneously in a high throughput fashion. Complex interaction between ECM-cell and ECM-growth factors affecting stem cell differentiation behavior can be readily deciphered in a time and cost effective way. Studies of human iPS cell differentiation to meso, endo and ecto germ layers, mesenchymal stem differentiation to pre-cardiomyocyte and others will be presented in this webinar presentation. 

After registering, you will receive a confirmation email containing information about joining the webinar.

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